Protective effect of Ocimum sanctum and Camellia sinensis on stress-induced oxidative damage in the central nervous system of Rattus norvegicus
نویسندگان
چکیده
Effect of aqueous extracts of Ocimum sanctum and Camellia sinensis on restraint stress-induced oxidative damage in the central nervous system (CNS) of R. norvegicus were evaluated in terms of lipid peroxidation (LPO), reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT). Restraint stress was used for 3h/day for 6 days consecutively, caused a significant elevation in LPO and reduction in GSH, SOD and CAT in cerebrum, cerebellum and brain stem. Post-treatment of O. sanctum and C. sinensis (100 mg/kg/day for 6 days) resulted in alteration of these parameters towards their control values. In conclusion, O. sanctum and C. sinensis posttreatment protected the CNS in different manner against restraint stress-induced oxidative damage in all three regions of brain.
منابع مشابه
Protective Effect of Composite Extract of Withania somnifera, Ocimum sanctum and Zingiber officinale on Swimming-Induced Reproductive Endocrine Dysfunctions in Male Rat
The present study has been designed to find out the effects of forced swimming-induced oxidative stress imposition on primary and secondary sex organs and its protection by plant extract in male Wistar strain rats. This work has been designed to find out the scientific basis of the local use of the composite extract of root of Withania somnifera, leaf of Ocimum sanctum and rhizome of Zingiber o...
متن کاملProtective Effect of Safranal, a Constituent of Crocus sativus, on Quinolinic Acid-induced Oxidative Damage in Rat Hippocampus
Objective(s): Quinolinic acid (QA)-mediated excitotoxicity has been widely used as a model for studying neurodegenerative disorders. Recent studies suggested that saffron (Crocus sativus) or its active metabolite, i.e. safranal, exerts pharmacological actions on central nervous system including anxiolytic, anticonvulsant, and neuroprotective properties. The present study aimed to investigate th...
متن کاملAmeliorative properties of aqueous extract of Ficus thonningii on erythrocyte osmotic fragility induced by acetaminophen in Rattus norvegicus
In vitro antioxidant and erythrocyte protecting activities by aqueous extract of Ficus thonningii leaves on blood cells were studied in acetaminophen treated rats. The extract was safe at limit dose of 5000 mg kg-1body weight. The extract demonstrated dose dependent antihemolytic effect at dose levels between 50 and 200 m...
متن کاملPlant medicine in the treatment of radiation-induced normal tissue lesions-A review
Radiation-induced normal tissue lesions, once seen as a consequence of loss of proliferative integrity of clonogenic target cells, inevitable and untreatable are now viewed as a result of dynamic interactions between multiple cell lines within a particular tissue that can be intervened. Normal tissue damage is the most important limiting factor in radiotherapy and a major component in the medic...
متن کاملExploring the potential effect of Ocimum sanctum in vincristine-induced neuropathic pain in rats
The present study was designed to investigate the ameliorative potential of Ocimum sanctum and its saponin rich fraction in vincristine-induced peripheral neuropathic pain in rats. Peripheral neuropathy was induced in rats by administration of vincristine sulfate (50 mug/kg i.p.) for 10 consecutive days. The mechanical hyperalgesia, cold allodynia, paw heat hyperalgesia and cold tail hyperalges...
متن کامل